Striatal-enriched protein tyrosine phosphatase modulates nociception
نویسندگان
چکیده
منابع مشابه
Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity
This commentary focuses on potential molecular mechanisms related to the dysfunctional synaptic plasticity that is associated with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Specifically, we focus on the role of striatal-enriched protein tyrosine phosphatase (STEP) in modulating synaptic function in these illnesses. STEP affects neuronal communication by op...
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We demonstrated previously that ethanol inhibition of NMDA receptor (NMDAR) function is accompanied by a reduction in tyrosine phosphorylation of Tyr1472 on the NR2B subunit, and this action of ethanol is attenuated by a broad spectrum tyrosine phosphatase inhibitor. Here we examined whether this ethanol inhibition of NMDAR activity was due to the actions of STriatal Enriched protein tyrosine P...
متن کاملSTEP61 regulates Pyk2 signaling STriatal-Enriched Protein Tyrosine Phosphatase (STEP) Regulates Pyk2 Activity*
Background: Proline-rich tyrosine kinase 2 (Pyk2) is implicated in synaptic plasticity; however, it remains unclear how Pyk2 is inactivated within neurons. Results: STriatal-Enriched Protein Tyrosine Phosphatase (STEP) directly binds to and dephosphorylates Pyk2 at Tyr. Conclusion: STEP inactivates Pyk2 and its downstream signaling pathways. Significance: These results identify an important reg...
متن کاملStriatal-Enriched Protein Tyrosine Phosphatase Controls Responses to Aversive Stimuli: Implication for Ethanol Drinking
The STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific phosphatase whose dysregulation in expression and/or activity is associated with several neuropsychiatric disorders. We recently showed that long-term excessive consumption of ethanol induces a sustained inhibition of STEP activity in the dorsomedial striatum (DMS) of mice. We further showed that down-regulation of ST...
متن کاملThe Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition
Striatal-enriched protein tyrosine phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer's disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function....
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ژورنال
عنوان ژورنال: Pain
سال: 2016
ISSN: 0304-3959
DOI: 10.1097/j.pain.0000000000000329